MAHENDRA THAPA

Phone: 9843817415

[email protected]

Qualities:

Chemistry graduate, hard working, honest and focused person with proven qualities in teaching and management, detail oriented, capable in identification of problems and solving it, quick to adapt to new environment and able to learn new techniques, friendly and outgoing person capable of working  independently as well as a team. Have excellent oral and written communication skills.

           

Teaching Experience:

• Member of subject evaluation committee, Chemistry, National examination Board, Sano Thimi.(present)
• Chemistry examiner; Cambridge International Examination, U.K.( present)
• Vice – principal, Kathmandu World School, Gundu, Bhaktapur; 2018 – 2020
• Head of the Department, Uniglobe Higher Secondary School; Kamaladi, Kathmandu; 2014 – 2018

• Graduate Teaching Assistant, Kansas State University; 2007-2012.
• Lecturer and coordinator at College of applied Science, Kathmandu Nepal; 2005-2007
• Lecturer and laboratory coordinator at Malpi College, Kathmandu, Nepal; 2005-2007
• Lab safety and chemical ordering in charge in Hua’s research laboratory, Kansas State University;
• Safety Class and radioactive material handling training;

Presentations:

• Mahendra Thapaand Duy H. Hua

Progress towards the Synthesis and Application of single walled carbon nano tubes ; 44th ACS Midwest Regional Meeting Omaha, NE, Oct 2009.

• Mahendra Thapa,Yunjeong Kim, Kyeong-Ok Changand Duy H. Hua

Synthesis and Antiviral activities of substituted Quercetins; 45th ACS Midwest Regional Meeting Wichita, KS, Oct 2010.

• Mahendra Thapa,Yunjeong Kim, Kyeong-Ok Changand Duy H. Hua

Synthesis and Antiviral activities of substituted Quercetins; 46th ACS Midwest Regional Meeting St. Louis, Mo, Oct 2011.

• Mahendra Thapa,and Rashidul Amin; Synthesis of various derivative of Resveratrol and its efficacy against influenza virus; Symmetry bioscience, Research Triangle Park, NC, July, 2012
• Mahendra Thapa,Shahid Alam and Maharvi Gulam; Structural modification of bupenorphine to decrease the body clearance. ; Symmetry bioscience, Research Triangle Park, NC, Jan, 2013
• Mahendra Thapa,and Rashidul Amin; Scale up and process development in the synthesis of prostaglandin; Symmetry bioscience, Research Triangle Park, NC, Mar, 2014
• Mahendra Thapa; Opportunity and challenges in the pharmaceutical industry in Nepal, Kathmandu Nepal June, 2016
• Mahendra Thapa; Comparision and possibility of research in Nepal and abroad; Biratnagar, Nepal, 2017 ( Invited talk)
• Mahendra Thapa; Opportunity and challenges of Nepali chemist in the pharmaceutical industry in Nepal, Kathmandu Nepal Oct, 2019; Nepal chemical Society( invited talk)

 

Research Experience:

• GMP batch production of Bimatoprost, Trovoprost and Latanoprost. 
• Gram scale production of derivatives of morphine, buprenorphine, hydromorphine and hydromorphone. 
• Process development of cyclosporine A formulation for clinical trial beginning early June 2014. 
• Synthesis and derivatization of Garners aldehyde and sphingosine. 
• Chemical synthesis of graphene like nano sheets
• Synthesis of resveretrol, and its derivatives
• Synthesis of Peg-Pei nanogels, Chitosan nanogels for interferon encapsulation
• Synthesis of tri-cyclic pyrones and its amide derivatives
• Synthesis of various derivatives of natural product quercetin and bio evaluation against human influenza virus.
• Synthesis of various peptides (linear and cyclic) as substrate for various viruses.
• Use of NMR, Mass Spectrometer, UV-Vis Spectroscopy, IR- Spectroscopy, HPLC, chromatography, AFM and Gel electrophoris  for analysis.
• Manage the lab chemicals and mentor Undergraduates.

 

Affiliations and offices held:

• Secretary of Chemistry student Association, Central department of Chemistry, Tribhuvan University, Kathmandu; 2003-2004.
• Treasurer of Nepalese Student Association (NSA), Kansas State University; 2008-2009.
• Secretary of Nepalese Student Association (NSA), Kansas State University; 2009-2010.
• Sports coordinator of Nepalese Student Association (NSA), Kansas State University; 2010-2011.
• Assistant Line manager; Symmetry BioSciences, Releigh, North Carolina; Aug 2012 – Jan 2013
• Assistant Line manager; Symmetry BioSciences, Releigh, North Carolina; Jan 2013 – Apr 2013
• Member of American Chemical Society.
• Life member of Nepal Chemical Society.
• Founding Life member of Kathmandu Institute of Applied Sciences.
• Board of Director, NIMS

 

Awards/ fellowship:

• Graduate fellowship; 2003-2005; Tribhuvan University, Kathmandu, Nepal
• Best teacher award; 2006, 2015, 2016, 2017, 2018
• Nominated for “Graduate Chemistry Research Award 2011” sponsored by Phi Lambda Epsilon (PLU), 2011.

Education:

·       PhD: Organic chemistry, Kansas State University                                                              2012

Dissertation title: Synthesis and anti-influenza activity of quercetin derivative and progress towards the synthesis of graphene.

• MS: organic chemistry, Central Department of Chemistry, Kirtipur, Kathmandu, Nepal.                     2005

Dissertation title: Isolation and Purification of bio-active compounds from Mint.

• BS: Chemistry (Biology Minor), Tri-Chandra Multiple College, Kathmandu, Nepal                      2003                                                                                  

Publications:

• Allan M. Prior, Mahendra Thapa, and Duy H. Hua.;“Aldose Reductase Inhibitors and Nanodelivery of Diabetic Therapeutics” Mini Reviews In Medicinal chemistry (2012), 12, 326-336.
• Thapa, Mahendra; Kim, Yunjeong; Chang, Kyeong-Ok; Hua, Duy H. ; “Synthesis and antiviral activity of substituted quercetins” Bioorganic & Medicinal Chemistry Letters(2012), 22(1), 353-356.
• Yunjeong Kim, Mahendra Thapa, Duy H Hua, and Kyeong-Ok Chang. : “Biodegradable nanogels for oral delivery of interferon for norovirus infection”. ‘Antiviral research(2011), 89(2), 165-73.
• Thapa, Mahendra: Situation of Drug development again Corona virus in Nepal, Nepalkhabar.com, 2020